The International Journal of Lower Extremity Wounds

HbA1c and Lower Extremity Amputation Risk in Patients With Diabetes: A Meta-Analysis

June 30, 2015

In this meta-analysis, we aimed to assess glycosylated hemoglobin (HbA1c) level and lower extremity amputation (LEA) risk in patients with diabetes. Systematic computerized searches of the PubMed and Web of Knowledge were performed. We compared HbA1c level between groups with LEA and without LEA by meta-analysis; we also examined the dose–response relationship between HbA1c level and LEA risk

Read the full article →

Underrecognized Peripheral Arterial Disease in Patients With Diabetes Mellitus in Thailand: We Must Consider Neuroischemic Foot Ulcers From This…

June 3, 2015

A range of prevalence of peripheral artery disease in diabetic patients has been estimated using the measurement of ankle brachial pressure index and clinical features in Asian countries. These data may be underestimates and hence underrecognized, raising questions about the numbers of patients with neuroischemic feet who are also at risk of diabetic foot ulcers

Read the full article →

Higher Levels of Serum Triglycerides Were Associated With Postoperative Deep Vein Thrombosis After Total Hip Arthroplasty in Patients With…

June 1, 2015

This retrospective study aimed to evaluate the association of serum lipids and deep vein thrombosis (DVT) risk following total hip arthroplasty (THA) in patients with nontraumatic osteonecrosis of the femoral head (ONFH). A total of 224 nontraumatic ONFH patients were enrolled

Read the full article →

Alginate and DNA Gels Are Suitable Delivery Systems for Diabetic Wound Healing

June 1, 2015

Diabetic foot ulcers (DFU) represent a severe health problem and an unmet clinical challenge. In this study, we tested the efficacy of novel biomaterials in improving wound healing in mouse models of diabetes mellitus (DM)

Read the full article →

Mesenchymal Stem Cells Suppress Fibroblast Proliferation and Reduce Skin Fibrosis Through a TGF-{beta}3-Dependent Activation

April 9, 2015

Recent studies showed that transplantation of mesenchymal stem cells (MSCs) significantly decreased tissue fibrosis; however, little attention has been paid to its efficacy on attenuating skin fibrosis, and the mechanism involved in its effect is poorly understood. In this work, we investigated the effects of MSCs on keloid fibroblasts and extracellular matrix deposition through paracrine actions and whether the antifibrotic properties of MSCs involved transforming growth factor-β (TGF-β)-dependent activation.

Read the full article →

Thank You Reviewers From IJLEW

April 9, 2015

Originally posted here: Thank You Reviewers From IJLEW

Read the full article →

Effectiveness of Platelet-Rich Plasma to Enhance Healing of Diabetic Foot Ulcers in Patients With Concomitant Peripheral Arterial Disease and Critical…

March 20, 2015

We sought to investigate the effect of autologous platelet-rich plasma (PRP) on the healing rate of diabetic foot ulcers in patients with diabetes and concomitant peripheral arterial disease (PAD). Diabetic patients with foot ulceration presenting with PAD who were treated with local growth factors in a single center, during a 24-month period from May 2009 to April 2011, were retrospectively reviewed.

Read the full article →

Effects of the Four-Herb Compound ANBP on Wound Healing Promotion in Diabetic Mice

March 20, 2015

Wound healing is a troublesome problem in diabetic patients. Besides, there is also an increased risk of postsurgical wound complications for diabetic patient

Read the full article →