September 16, 2012
Hemoglobin A1c predicts healing rate in diabetic wounds Before this study from colleagues from Hopkins and Penn, really very few manuscripts have shown a strong correlation. Adjusted β-coefficients and 95% confidence intervals for the relationship between change in wound area per day and other variables. Variable * Change in Wound Area Per Day (β) (cm 2 /day) P-Value Age (per 12 years) 0.017 (−0.065, 0.100) 0.680 Female (versus male) 0.038 (−0.132, 0.209) 0.659 African American race (versus white race) −0.063 (−0.174, 0.048) 0.263 Body mass index (per 9.76 kg/m 2 ), 0.053 (−0.032, 0.139) 0.220 Wound number (per 1.54 wounds) −0.001 (−0.059, 0.058) 0.982 Total cholesterol (per 44.7 mg/dl) −0.060 (−0.137, 0.017) 0.126 LDL cholesterol (per 41.5 mg/dl) 0.035 (−0.025, 0.094) 0.250 HDL cholesterol (per 15.9 mg/dl) −0.020 (−0.069, 0.029) 0.414 Triglycerides (per 75.4 mmol/l) −0.016 (−0.085, 0.052) 0.641 Systolic blood pressure (per 23.3 mmHg) 0.020 (−0.063, 0.102) 0.641 Diastolic blood pressure (per 13.5 mmHg) −0.074 (−0.151, 0.003) 0.060 Pulse (per 14.3 bpm) 0.025 (−0.037, 0.087) 0.432 Temperature (per 0.58 ° Fahrenheit) 0.015 (−0.048, 0.078) 0.639 White blood cell count (per 2490.42 cells/microliter) 0.118 (−0.085, 0.266) 0.119 Former smoker (versus never smoker) −0.015 (−0.224, 0.067) 0.862 Current smoker (versus never smoker) 0.054 (−0.103, 0.212) 0.496 Neuropathy (versus no neuropathy) −0.079 (−0.224, 0.067) 0.287 Peripheral artery disease (versus no peripheral artery disease) −0.053 (−0.144, 0.038) HbA1c (per 1.0% point) −0.028 (−0.054, −0.003) 0.027
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September 16, 2012
Scientists Make Progress in Tailor-Made Organs – NYTimes.com :
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