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News Story About Pharma Industry Payments – Response

March 13, 2013

I am sorry that it has been so long since I put up a post.  Things have been slightly hectic. Unfortunately, instead of reporting on new infectious disease information, with this entry I find myself responding to a story about my receiving payments to lecture from the pharmaceutical industry.  The story ran today (3/13/13) in the Philadelphia Inquirer and online at www.philly.com .  http://www.philly.com/philly/health/20130312_Philly_foot_doc_among_highest_paid_by_Big_Pharma.html When the original print story was run I had not had a chance to respond to the author, reporter Sam Woods.  I give Mr. Woods credit for updating the online story in response to some of my comments, reproduced below, which I emailed to him this morning.   I feel that the Pharma Industry has done an excellent job in disseminating important information that may otherwise not be available to those of us interested in saving limbs of patients with diabetes.  This is done in an unbiased, government approved and monitored way, under strict federal guidance.  My lectures are randomly, and independently audited for compliance with these guidelines and I have never been found to be deficient.  Here is my response to Mr

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Off Label Drug Promotion…Coming Soon?

December 12, 2012

(I want to thank my friend and colleague Jeff Karr, DPM ( www.osteomyelitiscenter.com ) for alerting me to this news story.) Just this past week the U.S.

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What’s New & Interesting in the Infectious Diseases Literature – Summer 2012

August 13, 2012

I confess…I have been a bit lackadaisical in my scanning through the journals I receive each month.  This point was driven home to me yesterday when I went to find room on my desk to put some work and realized it was totally covered with stacks of journal back issues I had put aside with all good intentions to eventually read through!  It was time to start clearing my desk with the side benefit of realizing I could probably come up with some interesting articles to blog about.  Well, I did.  In fact, I think I have enough for a few upcoming posts. Those of you who have heard me lecture on MRSA know that I am not a big fan of the use of trimethoprim/sulfamethoxazole for the treatment of even mild outpatient infections.  My main objection has been increased toxicity of this drug vs. other options including; Stevens-Johnson syndrome, renal toxicity, allergies, drug-drug interactions, etc.   However, I have also questioned the evidence supporting its use and have frequently stated that we don’t even know the proper dosing!  Most clinicians use this drug at the “standard” dose of 1 DS tablet bid (160mg/800mg).  However, some authorities have argued that that dose is too low for MRSA and an increased dose of 2 DS tabs bid should be used.  This has always concerned me because of the potential risk for increased adverse events with the higher dose.  A study published in the December 2011 (I told you I was behind on my reading!) Clinical Infectious Diseases by Cadena and colleagues compared the two dosing regimens and found no difference in outcomes with those treated with the higher dose vs.

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New 2012 IDSA Diabetic Foot Infection Guidelines

May 22, 2012

As promised, I would post a link to the newly revised, updated IDSA DFI Guidelines as soon as they were available.  Well, I am honored, proud and excited to be able to let my readership know that after about 6 years in writing, multiple levels of peer review and well over 60 individual review comments, that the newly revised guidelines have been posted by IDSA on their website. Here is the link:    http://www.idsociety.org/uploadedFiles/IDSA/Guidelines-Patient_Care/PDF_Library/2012%20Diabetic%20Foot%20Infections%20Guideline.pdf Those of you familiar with the 2004 document will immediately notice the changes.  All IDSA Guidelines are now standardized to a “question, recommendation, evidence summary” format.  Each committee is assigned to determine which are the most critical questions that need to be answered.  In this case, we came up with 10 questions that cover everything from diagnosis to antibiotics, to osteomyelitis and wound care.  There are 44 evidenced based recommendations that  guide the clinician in the answers to those 10 questions.  The evidence is then summarized and graded by the British Medical Journal “GRADE” system.  This common sense approach matches the strength of the recommendation with the level of the evidence.  This is given in plain English.  For example “Strong, Low” means that there is a strong recommendation but a relatively low level of evidence on which the decision has been based. I hope that you all find the new Guidelines helpful in your management of these patients.  I look forward to your comments

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Antibiotic Bone Penetration and Osteomyelitis

April 2, 2012

A reader of this site, Dr. Steven Klein, emailed me to ask the following questions.  I have obtained his permission to use his excellent thoughts as a “jumping off” point for this post and some subsequent ones to follow: You recently posted about the article:  ”Systemic Antibiotic Therapy for Chronic Oysteomyelitiis in Adults.” Spellberg, Brad and Lipsky, BA

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SCIP Surgical Prophylaxis?

November 13, 2011

One of the most frequent questions I am used to be asked is about when antibiotic prophylaxis should be used in performing foot and ankle surgery.  I have an entire lecture on this topic where I go through the data, or lack thereof, on the subject and suggest the clinical situations where prophy has traditionally been utilized (i.e. surgery longer than 2 hours, trauma surgery, immunocompromised hosts, etc).  More and more the question posed to me has become: “Warren, my hospital requires me to use prophylactic antibiotics even when I don’t feel they are necessary.  They have actually threatened to take away my surgical privileges if I don’t use them.  What can I do about that?”  Unfortunately, the answer is… not much

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Why I Don’t Eat Raw Oysters

August 15, 2011

The more I read the infectious disease literature the more my diet becomes limited. It seems that new reports of contaminated food are published regularly.  It gets to a point where you don’t know what you should and should not eat!  I have always been wary of raw foods and rarely eat sushi especially after an article was published in Clinical Infectious Diseases a number of years ago complete with pictures of the worm coughed up by a patient who ate salmon sushi (I apologize for not being able to find the reference and to those of you who love to eat sushi, it’s just not for me).

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Infection Control and Instrument Disinfection

July 25, 2011

This week I will be giving a talk to the Podiatric Assistants at the APMA National Meeting in Boston on the topic of office infection control.  I believe that this is an area which does not receive enough attention since it is far from “sexy” or cutting edge but is still important.  Last year I sat in on discussions by the Clinical Practices Committee of The American Podiatric Medical Association in an attempt to come up with some Guidelines for disinfection and sterilization of instruments for the podiatric physician.  This document, available online for members of APMA by searching the term “disinfection” in the Members Section at www.apma.org , incorporates information from the CDC document “ Guidelines for Disinfection and Sterilization in Healthcare Facilities, 2008 ” also available online at http://www.cdc.gov/hicpac/pdf/guidelines/Disinfection_Nov_2008.pdf .  Much of the CDC document is not directly applicable to daily office practice, thus the need for the specialized Guidelines.  In the APMA document we approached podiatric instrumentation much the same way as the dentist classify their instruments.  They are broken down into 3 categories: Critical Instruments : These are any object that enters sterile tissue or the vascular system and therefore must be sterile because any contamination could transmit disease.  These would include any instrument used in a surgical procedure.  These instruments should be sterilized. Semi-critical Instruments : These instruments contact non intact skin.  Examples would include tissue nippers or curettes used in debridement of an ulceration or incision and drainage of an abscess.  These devices require high level disinfection. Noncritical Instruments : These come in contact with intact skin or nails.

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Bugs and Drugs 2011 (Slide Show)

May 3, 2011

With this entry onto the blog I am trying something new.  The IT team at Data Trace has been working on a way to post a PowerPoint slide show to the blog.  We believe it is now ready to go.  For this first PowerPoint, I am posting the lecture I gave at DFCON 2011 in Hollywood, CA back in late March.  The topic is “Bugs and Drugs 2011″.  As sometimes happens at that excellent meeting, I did not have enough time to go through the entire talk so, even back then, I offered to put the lecture up on my blog for viewing.  I hope you find the information on the slides interesting and informative.  If you have any questions about any content or see a subject on which you would like me to expound on this site, please let me know.

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More on Antibiotics and Osteomyelitis

April 10, 2011

I have blogged a number of times about the questions surrounding some of the unknown, unproven issues surrounding the treatment of osteomyelitis including duration of antibiotic therapy and the “need” for surgical debridement. It continues to amaze me how it does not matter where, or to whom I lecture, if I ask the question “How long do you need to treat osteomyelitis and via what route?” the answer is always the same “4-6 WEEKS OF IV THERAPY” despite a total lack of human evidence to support that position. I recently came across an interesting paper that add to the ever increasing body of scientific literature that shows this old axiom is just not justified

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